P21

p21^Cip1 (ou p21^Waf1), également connue sous le nom de cyclin-dependent kinase inhibitor 1 ou CDK-interacting protein 1 est une protéine inhibitrice des CDK. Elle est connue pour inhiber les complexes CDK2 et CDK4 et permettre ainsi l'arrêt du cycle cellulaire. La protéine p53 est notamment connue pour être un régulateur de p21.

CDKN1A
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1AXC, 2ZVV, 2ZVW, 4RJF, 5E0U
Identifiants
Aliases	CDKN1A
IDs externes	OMIM: 116899 MGI: 104556 HomoloGene: 333 GeneCards: CDKN1A
Position du gène (Homme) Chr. Chromosome 6 humain Locus 6p21.2 Début 36,676,460 bp Fin 36,687,339 bp
Position du gène (Souris) Chr. Chromosome 17 (souris) Locus 17 A3.3|17 15.12 cM Début 29,309,950 bp Fin 29,319,701 bp
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans stromal cell of endometrium muqueuse gastrique veine cave left uterine tube cellule bêta aorte ascendante Veine saphène artère poplitée Tibial arteries Descending thoracic aorta Fortement exprimé dans stroma of bone marrow calvaria molaire antre du pylore lèvre œsophage follicule pileux epithelium of stomach skin of external ear endothelial cell of lymphatic vessel Plus de données d'expression de référence BioGPS Plus de données d'expression de référence
Gene Ontology Fonction moléculaire liaison ion métal liaison protéique cyclin-dependent protein serine/threonine kinase inhibitor activity ubiquitin protein ligase binding cyclin binding cyclin-dependent protein kinase activating kinase activity cyclin-dependent protein serine/threonine kinase activity protein kinase inhibitor activity protein kinase binding liaison de complexe macromoléculaire Composant cellulaire cytoplasme cytosol cyclin-dependent protein kinase holoenzyme complex PCNA-p21 complex perinuclear region of cytoplasm noyau nucléoplasme nucléole corps nucléaire complexe macromoléculaire Processus biologique cellular response to extracellular stimulus signal transduction by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator cellular response to heat regulation of cyclin-dependent protein serine/threonine kinase activity DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest positive regulation of cell death response to organic cyclic compound negative regulation of cyclin-dependent protein serine/threonine kinase activity stress-induced premature senescence positive regulation of fibroblast proliferation replicative senescence response to hyperoxia response to corticosterone cellular response to amino acid starvation positive regulation of programmed cell death negative regulation of apoptotic process response to glucocorticoid response to arsenic-containing substance regulation of DNA biosynthetic process response to organic substance negative regulation of gene expression cellular response to DNA damage stimulus negative regulation of G1/S transition of mitotic cell cycle régulation du cycle cellulaire intrinsic apoptotic signaling pathway sénescence cellulaire positive regulation of reactive oxygen species metabolic process cellular response to UV-B G2/M transition of mitotic cell cycle positive regulation of B cell proliferation negative regulation of cell growth response to organonitrogen compound animal organ regeneration regulation of mitotic cell cycle intestinal epithelial cell maturation cellular response to ionizing radiation cycle cellulaire Ras protein signal transduction negative regulation of phosphorylation réponse à une substance toxique response to UV response to X-ray negative regulation of cell population proliferation protein stabilization positive regulation of cyclin-dependent protein kinase activity regulation of transcription by RNA polymerase II DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator positive regulation of protein kinase activity cellular response to gamma radiation negative regulation of cyclin-dependent protein kinase activity transcription initiation from RNA polymerase II promoter G1/S transition of mitotic cell cycle cytokine-mediated signaling pathway negative regulation of vascular associated smooth muscle cell proliferation Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 1026 12575 Ensembl ENSG00000124762 ENSMUSG00000023067 UniProt P38936 P39689 RefSeq (mRNA) NM_078467 NM_000389 NM_001220777 NM_001220778 NM_001291549 NM_001111099 NM_007669 RefSeq (protéine) NP_000380 NP_001207706 NP_001207707 NP_001278478 NP_510867 NP_001361438 NP_001361439 NP_001361440 NP_001361441 NP_001361442 NP_001104569 NP_031695 Localisation (UCSC) Chr 6: 36.68 – 36.69 Mb Chr 17: 29.31 – 29.32 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

p21 permet également l'importation du complexe CDK4/6-CyclineD1 dans le noyau grâce à sa séquence NLS.

La protéine p21 est codée par le gène CDKN1A, localisé sur le chromosome 6 humain.