LYN (protéine)

LYN est une protéine de type tyrosine kinase dont le gène est le LYN situé sur le chromosome 8 humain.

LYN
Structures disponibles PDB Recherche d'orthologue: PDBe RCSB Identifiants PDB 1W1F, 1WA7, 3A4O
Identifiants
Aliases	LYN
IDs externes	OMIM: 165120 MGI: 96892 HomoloGene: 55649 GeneCards: LYN
Position du gène (Homme) Chr. Chromosome 8 humain Locus 8q12.1 Début 55,879,835 bp Fin 56,014,169 bp
Position du gène (Souris) Chr. Chromosome 4 (souris) Locus 4 A1|4 2.05 cM Début 3,678,115 bp Fin 3,813,122 bp
Expression génétique Bgee Humain Souris (orthologue) Fortement exprimé dans monocyte sang palpebral conjunctiva moelle osseuse nasal epithelium cellule de la moelle osseuse appendice iléo-cæcal ligament alvéolo-dentaire granulocyte os spongieux Fortement exprimé dans stroma of bone marrow granulocyte sang ganglion mésentérique Vasculature of brain rate tibiofemoral joint lobe pulmonaire droit poumon gauche left lung lobe Plus de données d'expression de référence BioGPS n/a
Gene Ontology Fonction moléculaire transmembrane transporter binding SH3 domain binding liaison de complexe macromoléculaire activité kinase gamma-tubulin binding signaling receptor binding liaison ATP protein kinase activity non-membrane spanning protein tyrosine kinase activity liaison enzymatique activité de transférase platelet-derived growth factor receptor binding integrin binding liaison protéique glycosphingolipid binding protein tyrosine kinase activity liaison nucléotide phosphoprotein binding ubiquitin protein ligase binding ephrin receptor binding phosphorylation-dependent protein binding Composant cellulaire cytoplasme cytosol membrane extrinsic component of cytoplasmic side of plasma membrane mitochondrial intermembrane space perinuclear region of cytoplasm noyau mitochondrial membranes radeau lipidique exosome appareil de Golgi membrane plasmique postsynaptic density mast cell granule integrin alpha2-beta1 complex Crête mitochondriale intracellular membrane-bounded organelle glutamatergic synapse postsynaptic specialization, intracellular component Processus biologique regulation of protein phosphorylation cellular response to extracellular stimulus cellular response to retinoic acid positive regulation of B cell receptor signaling pathway tolerance induction to self antigen regulation of mast cell activation regulation of cell adhesion mediated by integrin cellular response to heat response to amino acid hématopoïèse adaptive immune response regulation of erythrocyte differentiation cellular response to DNA damage stimulus positive regulation of Fc receptor mediated stimulatory signaling pathway platelet activation Fc-epsilon receptor signaling pathway phosphorylation des protéines regulation of B cell apoptotic process positive regulation of dendritic cell apoptotic process positive regulation of glial cell proliferation response to carbohydrate regulation of platelet aggregation negative regulation of cell population proliferation B cell receptor signaling pathway negative regulation of myeloid leukocyte differentiation dendritic cell differentiation Fc receptor mediated inhibitory signaling pathway Fc-gamma receptor signaling pathway involved in phagocytosis transmembrane receptor protein tyrosine kinase signaling pathway regulation of B cell receptor signaling pathway stimulatory C-type lectin receptor signaling pathway response to sterol depletion positive regulation of stress-activated protein kinase signaling cascade regulation of cytokine production response to insulin positive regulation of mast cell proliferation negative regulation of MAP kinase activity regulation of ERK1 and ERK2 cascade positive regulation of peptidyl-tyrosine phosphorylation erythrocyte differentiation protein autophosphorylation oligodendrocyte development regulation of mast cell degranulation positive regulation of phosphorylation viral process réponse à une substance toxique negative regulation of protein phosphorylation Fc receptor mediated stimulatory signaling pathway growth hormone receptor signaling pathway via JAK-STAT phosphorylation processus du système immunitaire regulation of release of sequestered calcium ion into cytosol positive regulation of tyrosine phosphorylation of STAT protein B cell homeostasis immune response-regulating cell surface receptor signaling pathway response to axon injury negative regulation of mast cell proliferation regulation of inflammatory response peptidyl-tyrosine autophosphorylation response to hormone regulation of monocyte chemotaxis leukocyte migration lipopolysaccharide-mediated signaling pathway histamine secretion by mast cell intracellular signal transduction response to organic cyclic compound negative regulation of intracellular signal transduction positive regulation of cell migration ephrin receptor signaling pathway negative regulation of toll-like receptor 2 signaling pathway T cell costimulation response to peptide hormone platelet degranulation coagulation sanguine positive regulation of phosphatidylinositol 3-kinase activity positive regulation of oligodendrocyte progenitor proliferation negative regulation of immune response positive regulation of cell population proliferation positive regulation of neuron projection development negative regulation of ERK1 and ERK2 cascade peptidyl-tyrosine phosphorylation negative regulation of B cell proliferation negative regulation of toll-like receptor 4 signaling pathway transduction de signal système immunitaire inné neuron projection development central nervous system development réponse inflammatoire positive regulation of protein phosphorylation positive regulation of phosphatidylinositol 3-kinase signaling différenciation cellulaire positive regulation of Ras protein signal transduction positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process Sources:Amigo / QuickGO
Orthologues Espèces Homme Souris Entrez 4067 17096 Ensembl ENSG00000254087 ENSMUSG00000042228 UniProt P07948 P25911 RefSeq (mRNA) NM_001111097 NM_002350 NM_001111096 NM_010747 RefSeq (protéine) NP_001104567 NP_002341 NP_001104566 NP_034877 Localisation (UCSC) Chr 8: 55.88 – 56.01 Mb Chr 4: 3.68 – 3.81 Mb Publication PubMed
Wikidata
Voir/Editer Humain Voir/Editer Souris

En médecine

Une mutation du gène LYN confère une résistance aux anti-œstrogènes des cancers du sein avec récepteurs à l’œstrogène. D'autres mutations sont associées avec un risque accru de survenue d'un lupus érythémateux disséminé.

Cible thérapeutique

Le dasatinib inhibe l'activité du LYN.