CSF1R

CSF1R
	Structure de la protéine CSF1R. Basé sur l'identifiant PDB 2I0V.
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	2I0V, 2I0Y, 2I1M, 2OGV, 3BEA, 3DPK, 3KRJ, 3KRL, 3LCD, 3LCO, 4DKD, 4HW7, 4LIQ, 4R7H, 4R7I, 4WRL, 4WRM
Identifiants
Aliases	CSF1R, Colony stimulating factor 1 receptor
IDs externes	OMIM: 164770 MGI: 1339758 HomoloGene: 3817 GeneCards: CSF1R
Nomenclature EC	2.7.10.1
Position du gène (Homme)
Chr.	Chromosome 5 humain
Fin	150,113,372 bp
Position du gène (Souris)
Chr.	Chromosome 18 (souris)
Fin	61,265,221 bp
Expression génétique
	Fortement exprimé dans
	granulocyte; ; monocyte; ; rate; ; artère coronaire droite; ; placenta; ; ganglion inférieur du nerf vague; ; épithélium pigmentaire rétinien; ; vésicule biliaire; ; appendice iléo-cæcal; ; ganglion lymphatique;
	Fortement exprimé dans
	stroma of bone marrow; ; épithélium pigmentaire rétinien; ; cheville; ; motoneurone; ; tibiofemoral joint; ; artère carotide interne; ; calvaria; ; substantia nigra; ; gastrula; ; globus pallidus;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	liaison nucléotide; protein tyrosine kinase activity; protein kinase activity; activité de transférase; transmembrane receptor protein tyrosine kinase activity; activité kinase; protein homodimerization activity; liaison ATP; protein phosphatase binding; macrophage colony-stimulating factor receptor activity; cytokine binding; liaison protéique; Récepteurs à activité tyrosine kinase; transmembrane signaling receptor activity;
Composant cellulaire	integral component of membrane; integral component of plasma membrane; membrane; surface cellulaire; CSF1-CSF1R complex; nucléoplasme; membrane plasmique; intracellular membrane-bounded organelle; cytoplasme; receptor complex;
Processus biologique	negative regulation of cell population proliferation; transmembrane receptor protein tyrosine kinase signaling pathway; positive regulation of protein serine/threonine kinase activity; mammary gland duct morphogenesis; positive regulation of cell motility; macrophage colony-stimulating factor signaling pathway; phosphatidylinositol-mediated signaling; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; transduction de signal; Guidage axonal; développent d'un organisme multicellulaire; monocyte differentiation; macrophage differentiation; ruffle organization; positive regulation of cell migration; cellular response to cytokine stimulus; protein autophosphorylation; peptidyl-tyrosine phosphorylation; olfactory bulb development; regulation of bone resorption; phosphatidylinositol metabolic process; phosphorylation des protéines; positive regulation of protein tyrosine kinase activity; cell-cell junction maintenance; osteoclast differentiation; système immunitaire inné; regulation of actin cytoskeleton reorganization; processus du système immunitaire; réponse inflammatoire; positive regulation of protein phosphorylation; forebrain neuron differentiation; phosphorylation; cellular response to macrophage colony-stimulating factor stimulus; positive regulation of cell population proliferation; regulation of cell shape; prolifération cellulaire; positive regulation of tyrosine phosphorylation of STAT protein; cytokine-mediated signaling pathway; hématopoïèse; negative regulation of signal transduction; différenciation cellulaire; hematopoietic progenitor cell differentiation; positive regulation of MAPK cascade; response to ischemia; microglial cell proliferation; positive regulation by host of viral process;
	Sources:Amigo / QuickGO
Orthologues
	1436
	12978
	ENSG00000182578
	ENSMUSG00000024621
	P07333
	P09581
	NM_001288705; NM_005211; NM_001349736; NM_001375320; NM_001375321
	NM_001037859; NM_007779
	NP_001275634; NP_005202; NP_001336665; NP_001362249; NP_001362250
	NP_001032948
	Wikidata
Voir/Editer Humain	Voir/Editer Souris