BACH2

BACH2
Structures disponibles
PDB	Recherche d'orthologue: PDBe RCSB
Identifiants PDB
	3OHU, 3OHV
Identifiants
Aliases	BACH2
IDs externes	OMIM: 605394 MGI: 894679 HomoloGene: 7240 GeneCards: BACH2
Position du gène (Homme)
Chr.	Chromosome 6 humain
Fin	90,296,843 bp
Position du gène (Souris)
Chr.	Chromosome 4 (souris)
Fin	32,586,108 bp
Expression génétique
	Fortement exprimé dans
	nerf sural; ; epithelium of nasopharynx; ; ovocyte; ; moelle osseuse; ; secondary oocyte; ; thymus; ; éminence ganglionnaire; ; tonsille; ; ganglion lymphatique; ; ventricular zone;
	Fortement exprimé dans
	zygote; ; ganglion mésentérique; ; Ganglion de Gasser; ; Rostral migratory stream; ; sang; ; tibiofemoral joint; ; rate; ; main; ; follicule pileux; ; éminence ganglionnaire;
	Plus de données d'expression de référence
	Plus de données d'expression de référence
Gene Ontology
Fonction moléculaire	DNA-binding transcription factor activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; liaison ADN; DNA-binding transcription repressor activity, RNA polymerase II-specific; ubiquitin-protein transferase activity; DNA-binding transcription factor activity, RNA polymerase II-specific;
Composant cellulaire	cytoplasme; Cul3-RING ubiquitin ligase complex; noyau; cytosol;
Processus biologique	regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription by RNA polymerase II; transcription, DNA-templated; Ubiquitination; import into nucleus;
	Sources:Amigo / QuickGO
Orthologues
	60468
	12014
	ENSG00000112182
	ENSMUSG00000040270
	Q9BYV9
	P97303
	NM_001170794; NM_021813
	NM_001109661; NM_007521
	NP_001164265; NP_068585
	NP_001103131
	Wikidata
Voir/Editer Humain	Voir/Editer Souris

Le BACH2 est un facteur de transcription dont le gène est BACH2 situé sur le chromosome 6 humain.

Rôles

Exprimé dans les lymphocytes B, il intervient dans la commutation isotypique^[5], processus qui permet de changer l'isotype (classe) des immunoglobulines produites, et ce, en augmentant l'expression de BLIMP1^[6]. Il joue également dans la différenciation des lymphocytes T auxiliaires^[7] et favorise le développement des lymphocytes T régulateurs^[8].

Ce facteur est également nécessaire pour la maturation des macrophages alvéolaires au niveau pulmonaire, ainsi que pour la régulation du surfactant^[9].

Il intervient dans l'immunosuppression des tumeurs, favorisant l'expansion de ces dernières^[10].

En médecine

Une mutation du gène est associée avec le risque de survenue d'une maladie de Crohn^[11], d'un diabète de type 1^[12] ou d'un asthme^[13].

Notes et références

↑ ^{a b et c} GRCh38: Ensembl release 89: ENSG00000112182 - Ensembl, May 2017
↑ ^{a b et c} GRCm38: Ensembl release 89: ENSMUSG00000040270 - Ensembl, May 2017
↑ « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine
↑ Muto A, Tashiro S, Nakajima O et al. The transcriptional programme of antibody class switching involves the repressor Bach2, Nature, 2004;429:566–571
↑ Muto A, Ochiai K, Kimura Y et al. Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch, EMBO J, 2010;29:4048–4061
↑ Roychoudhuri R, Hirahara K, Mousavi K et al. BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis, Nature, 2013;498:506–510
↑ Kim EH, Gasper DJ, Lee SH, Plisch EH, Svaren J, Suresh M; Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice, J Immunol, 2014;192:985–995
↑ Nakamura A, Ebina-Shibuya R, Itoh-Nakadai A et al. Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function, J Exp Med, 2013;210:2191–2204
↑ Roychoudhuri R, Eil1 RL, Clever D et al. The transcription factor BACH2 promotes tumor immunosuppression, J Clin Invest, 2016;126:599-604
↑ Franke A, McGovern DP, Barrett JC et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci, Nat Genet, 2010;42:1118–1125
↑ Cooper JD, Smyth DJ, Smiles AM et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci, Nat Genet, 2008;40:1399–1401
↑ Ferreira MA, Matheson MC, Duffy DL et al. Identification of IL6R and chromosome 11q13.5 as risk loci for asthma, Lancet, 2011;378:1006–1014

[refGRCh38Ensembl-1] {a b et c} GRCh38: Ensembl release 89: ENSG00000112182 - Ensembl, May 2017

[refGRCm38Ensembl-2] {a b et c} GRCm38: Ensembl release 89: ENSMUSG00000040270 - Ensembl, May 2017

[3] « Publications PubMed pour l'Homme », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[4] « Publications PubMed pour la Souris », sur National Center for Biotechnology Information, U.S. National Library of Medicine

[Muto_2004-5] Muto A, Tashiro S, Nakajima O et al. The transcriptional programme of antibody class switching involves the repressor Bach2, Nature, 2004;429:566–571

[Muto_2010-6] Muto A, Ochiai K, Kimura Y et al. Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch, EMBO J, 2010;29:4048–4061

[Roychoudhuri_2013-7] Roychoudhuri R, Hirahara K, Mousavi K et al. BACH2 represses effector programs to stabilize T(reg)-mediated immune homeostasis, Nature, 2013;498:506–510

[Kim_2014-8] Kim EH, Gasper DJ, Lee SH, Plisch EH, Svaren J, Suresh M; Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice, J Immunol, 2014;192:985–995

[Nakamura_2013-9] Nakamura A, Ebina-Shibuya R, Itoh-Nakadai A et al. Transcription repressor Bach2 is required for pulmonary surfactant homeostasis and alveolar macrophage function, J Exp Med, 2013;210:2191–2204

[Roychoudhuri_2016-10] Roychoudhuri R, Eil1 RL, Clever D et al. The transcription factor BACH2 promotes tumor immunosuppression, J Clin Invest, 2016;126:599-604

[Franke_2010-11] Franke A, McGovern DP, Barrett JC et al. Genome-wide meta-analysis increases to 71 the number of confirmed Crohn’s disease susceptibility loci, Nat Genet, 2010;42:1118–1125

[Cooper_2008-12] Cooper JD, Smyth DJ, Smiles AM et al. Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci, Nat Genet, 2008;40:1399–1401

[Ferreira_2011-13] Ferreira MA, Matheson MC, Duffy DL et al. Identification of IL6R and chromosome 11q13.5 as risk loci for asthma, Lancet, 2011;378:1006–1014

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