Abiétadiène synthase
L’abiétadiène synthase est une lyase qui catalyse la réaction : (+)-copalyl-pyrophosphate abiéta-7,13-diène + pyrophosphate.
Abiéta-7,13-diène synthase
| N° EC | EC |
|---|---|
| N° CAS | |
| Cofacteur(s) | Mg2+ |
| IUBMB | Entrée IUBMB |
|---|---|
| IntEnz | Vue IntEnz |
| BRENDA | Entrée BRENDA |
| KEGG | Entrée KEGG |
| MetaCyc | Voie métabolique |
| PRIAM | Profil |
| PDB | RCSB PDB PDBe PDBj PDBsum |
| GO | AmiGO / EGO |
Cette enzyme intervient dans la biosynthèse des diterpénoïdes.
Notes et références
modifier- (en) RB, JE Flory, R Jetter, MM Ravn, HJ Lee, RM Coates et RB Croteau, « Abietadiene synthase from grand fir (Abies grandis): characterization and mechanism of action of the "pseudomature" recombinant enzyme », Biochemistry., vol. 39, no 50, , p. 15592–602 (PMID 11112547, DOI 10.1021/bi001997l)
- (en) Peters RJ, Ravn MM, Coates RM, Croteau RB, « Bifunctional abietadiene synthase: free diffusive transfer of the (+)-copalyl diphosphate intermediate between two distinct active sites », J. Am. Chem. Soc., vol. 123, no 37, , p. 8974–8 (PMID 11552804, DOI 10.1021/ja010670k)
- (en) Peters RJ, Croteau RB, « Abietadiene synthase catalysis: mutational analysis of a prenyl diphosphate ionization-initiated cyclization and rearrangement », Proc. Natl. Acad. Sci. U.S.A., vol. 99, no 2, , p. 580–4 (PMID 11805316, PMCID 117348, DOI 10.1073/pnas.022627099)
- (en) Peters RJ, Croteau RB, « Abietadiene synthase catalysis: conserved residues involved in protonation-initiated cyclization of geranylgeranyl diphosphate to (+)-copalyl diphosphate », Biochemistry., vol. 41, no 6, , p. 1836–42 (PMID 11827528, DOI 10.1021/bi011879d)
- (en) Ravn MM, Peters RJ, Coates RM, Croteau R, « Mechanism of abietadiene synthase catalysis: stereochemistry and stabilization of the cryptic pimarenyl carbocation intermediates », J. Am. Chem. Soc., vol. 124, no 24, , p. 6998–7006 (PMID 12059223, DOI 10.1021/ja017734b)
- (en) Keeling CI, Madilao LL, Zerbe P, Dullat HK, Bohlmann J, « The primary diterpene synthase products of Picea abies levopimaradiene/abietadiene synthase (PaLAS) are epimers of a thermally unstable diterpenol », J. Biol. Chem., vol. 286, no 24, , p. 21145-21153 (PMID 21518766, PMCID 3122176, DOI 10.1074/jbc.M111.245951)
- (en) Hall DE, Zerbe P, Jancsik S, Quesada AL, Dullat H, Madilao LL, Yuen M, Bohlmann J, « Evolution of conifer diterpene synthases: diterpene resin acid biosynthesis in lodgepole pine and jack pine involves monofunctional and bifunctional diterpene synthases », Plant Physiol., vol. 161, no 2, , p. 600-616 (PMID 23370714, PMCID 3561007, DOI 10.1104/pp.112.208546)
